Tuesday, April 21, 2009
The TCF21 gene is found on chromosome 6 in a region known as 6q23-24. Methylation of this gene is risk factor for head and neck squamous cell carcinomas, non-small cell lung, breast and ovarian cancer, melanoma and lymphoma. Silencing the gene in epithelial cells through methylation effectively turns them into mesenchymal cells. Maybe we should drink more green tea.