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Friday, March 30, 2018

The following is my comment today on a YouTube myeloma  survivor video:

    In the case of multiple myeloma,  there is an incredible amount of new research.   There are so many new treatments that are extending lifespans, although the talk of cure is an exaggeration.  Current treatments only seem to kill the mature myeloma cell and not the progenitor cells which eventually bring back the disease once the immune system looses control and the treatment is stopped or ceases to work. The most promising FDA approved treatment at the moment in terms of hazard risk is an antibody infusion of Daratumumab, which unleashes the patient's immune system against the disease.  It probably needs to be combined with an  HDAC6 inhibitor to be most effective.  HDAC6 inhibitors increase the number of CD38 receptors on myeloma cells while the do not effect the CD38 expression on lymphocytes.  Eating pancreas glandulars has the opposite effect on myeloma cells.  So, that is probably the worst thing to eat while undergoing Daratumumab treatment. 

    Many foods effective against cancer are so, because they are HDAC inhibitors. The most promising chemical in food for controlling the disease is emodin although you find no information about it outside research papers.  The worst nutrient for people with the disease is probably hyaluronic acid, since that is what researchers now use to grow the disease in the lab. The best source of information is possibly Google Scholar working back from present to the past.  The biggest problem with advice and information is that it is out of date and now known to be false. This comment is not intended as medical advice, but an attempt the stir ones curiosity about all the options for treating the disease.   Of the incurable cancers, multiple myeloma is considered to be one of the most treatable.

Saturday, July 4, 2015


Multiple Myeloma

Multiple Myeloma is a cancer of the plasma cells.  Cytoma formation is generally restricted to the bone marrow and the infiltration of the skeletal structure including both the interior and surface of the bone. The disease favors the creation of osteoclasts over osteoblasts resulting in the resorption of bone mass.  It begins with the central skeleton and expands to the hand and feet extremities. Reaching the hand and feet is rare unless bone destruction is arrested, because disintegration of bones in the central skeleton is generally fatal.   Progression of the disease crowds out the normal functioning of the bone marrow. This results in anemia and immune suppression. Also, the production of abnormal proteins can lead to the failure of kidney function.

Four independent factors come together to produce the disease state.  These are categorized as (1) genetic, (2) epigenetic, (3) viral, and (4) hormonal. 

(1)    Genetic damage results from the accumulation of strontium-90 in the developing skeleton.  Strontium-90 decays into short lived radioactive elements which decay and irradiate the stem cells in the bone marrow niches causing the genetic damage. 

(2)    Epigenetic research points primarily to the thymus and secondarily to the brain as the probable cause of Multiple Myeloma.  How the myeloma progenitor cells mature into actual myeloma cells is not completely understood.  Protease inhibitors only kill the mature myeloma cells and do not affect progenitor cells from any of the known lines of myeloma.  Myeloma cells can develop a pump mechanism to rid themselves of a particular protease inhibitor.  Paw Paw Cell Regulator and possibly Sodium DichloroAcetate may reduce the energy level in a Myeloma cell so it is unable pump out the protease inhibitor.

(3)    Plasma stem cells travel from the bone marrow niches to the spleen and lymph nodes where they encounter viral antigens which are crucial to appropriate responses to viral infections and to the development of Multiple Myeloma.

(4)    Hormonal responses to stress, nutrition, toxins, and other environmental factors compromise the immune system and allow the disease process to gain a foothold from which it can further suppress the immune system. The cancer makes demands on the body’s supply of vitamin C and the body’s ability to store vitamin D.  Lowering the levels of Interleukin-6 is also crucial to controlling the progression of the disease.

Thursday, May 1, 2014

Emerging Trends in Multiple Myeloma


metformin - 500mg before each meal.
Omeprazol is a stomach protector that needs to be taken about one hour before the metformin pill.

Phenformin, a derivative of the widely-used diabetes drug metformin is being developed specifically as an anti-cancer agent by the Salk Institute.