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Saturday, July 4, 2015

Multiple Myeloma

Multiple Myeloma is a cancer of the plasma cells.  Cytoma formation is generally restricted to the bone marrow and the infiltration of the skeletal structure including both the interior and surface of the bone. The disease favors the creation of osteoclasts over osteoblasts resulting in the resorption of bone mass.  It begins with the central skeleton and expands to the hand and feet extremities. Reaching the hand and feet is rare unless bone destruction is arrested, because disintegration of bones in the central skeleton is generally fatal.   Progression of the disease crowds out the normal functioning of the bone marrow. This results in anemia and immune suppression. Also, the production of abnormal proteins can lead to the failure of kidney function.

Four independent factors come together to produce the disease state.  These are categorized as (1) genetic, (2) epigenetic, (3) viral, and (4) hormonal. 

(1)    Genetic damage results from the accumulation of strontium-90 in the developing skeleton.  Strontium-90 decays into short lived radioactive elements which decay and irradiate the stem cells in the bone marrow niches causing the genetic damage. 

(2)    Epigenetic research points primarily to the thymus and secondarily to the brain as the probable cause of Multiple Myeloma.  How the myeloma progenitor cells mature into actual myeloma cells is not completely understood.  Protease inhibitors only kill the mature myeloma cells and do not affect progenitor cells from any of the known lines of myeloma.  Myeloma cells can develop a pump mechanism to rid themselves of a particular protease inhibitor.  Paw Paw Cell Regulator and possibly Sodium DichloroAcetate may reduce the energy level in a Myeloma cell so it is unable pump out the protease inhibitor.

(3)    Plasma stem cells travel from the bone marrow niches to the spleen and lymph nodes where they encounter viral antigens which are crucial to appropriate responses to viral infections and to the development of Multiple Myeloma.

(4)    Hormonal responses to stress, nutrition, toxins, and other environmental factors compromise the immune system and allow the disease process to gain a foothold from which it can further suppress the immune system. The cancer makes demands on the body’s supply of vitamin C and the body’s ability to store vitamin D.  Lowering the levels of Interleukin-6 is also crucial to controlling the progression of the disease.

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