The following is my comment today on a YouTube myeloma  survivor video:

    In the case of multiple myeloma,  there is an incredible amount of new research.   There are so many new treatments that are extending lifespans, although the talk of cure is an exaggeration.  Current treatments only seem to kill the mature myeloma cell and not the progenitor cells which eventually bring back the disease once the immune system looses control and the treatment is stopped or ceases to work. The most promising FDA approved treatment at the moment in terms of hazard risk is an antibody infusion of Daratumumab, which unleashes the patient's immune system against the disease.  It probably needs to be combined with an  HDAC6 inhibitor to be most effective.  HDAC6 inhibitors increase the number of CD38 receptors on myeloma cells while the do not effect the CD38 expression on lymphocytes.  Eating pancreas glandulars has the opposite effect on myeloma cells.  So, that is probably the worst thing to eat while undergoing Daratumumab treatment. 

    Many foods effective against cancer are so, because they are HDAC inhibitors. The most promising chemical in food for controlling the disease is emodin although you find no information about it outside research papers.  The worst nutrient for people with the disease is probably hyaluronic acid, since that is what researchers now use to grow the disease in the lab. The best source of information is possibly Google Scholar working back from present to the past.  The biggest problem with advice and information is that it is out of date and now known to be false. This comment is not intended as medical advice, but an attempt the stir ones curiosity about all the options for treating the disease.   Of the incurable cancers, multiple myeloma is considered to be one of the most treatable.

My favorite vehicle

Friendship

Multiple Myeloma

Multiple Myeloma is a cancer of the plasma cells.  Cytoma formation is generally restricted to the bone marrow and the infiltration of the skeletal structure including both the interior and surface of the bone. The disease favors the creation of osteoclasts over osteoblasts resulting in the resorption of bone mass.  It begins with the central skeleton and expands to the hand and feet extremities. Reaching the hand and feet is rare unless bone destruction is arrested, because disintegration of bones in the central skeleton is generally fatal.   Progression of the disease crowds out the normal functioning of the bone marrow. This results in anemia and immune suppression. Also, the production of abnormal proteins can lead to the failure of kidney function.

Four independent factors come together to produce the disease state.  These are categorized as (1) genetic, (2) epigenetic, (3) viral, and (4) hormonal. 

(1)    Genetic damage results from the accumulation of strontium-90 in the developing skeleton.  Strontium-90 decays into short lived radioactive elements which decay and irradiate the stem cells in the bone marrow niches causing the genetic damage. 

(2)    Epigenetic research points primarily to the thymus and secondarily to the brain as the probable cause of Multiple Myeloma.  How the myeloma progenitor cells mature into actual myeloma cells is not completely understood.  Protease inhibitors only kill the mature myeloma cells and do not affect progenitor cells from any of the known lines of myeloma.  Myeloma cells can develop a pump mechanism to rid themselves of a particular protease inhibitor.  Paw Paw Cell Regulator and possibly Sodium DichloroAcetate may reduce the energy level in a Myeloma cell so it is unable pump out the protease inhibitor.

(3)    Plasma stem cells travel from the bone marrow niches to the spleen and lymph nodes where they encounter viral antigens which are crucial to appropriate responses to viral infections and to the development of Multiple Myeloma.

(4)    Hormonal responses to stress, nutrition, toxins, and other environmental factors compromise the immune system and allow the disease process to gain a foothold from which it can further suppress the immune system. The cancer makes demands on the body’s supply of vitamin C and the body’s ability to store vitamin D.  Lowering the levels of Interleukin-6 is also crucial to controlling the progression of the disease.

A Wintery Swedish Lesson

Persian: لاله پورکریم‎, pronounced [lɒːle-je puːɾkæɾiːm]

multiple myeloma

Nitinol Heat Machines

Emerging Trends in Multiple Myeloma

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metformin - 500mg before each meal.
Omeprazol is a stomach protector that needs to be taken about one hour before the metformin pill.



Phenformin, a derivative of the widely-used diabetes drug metformin is being developed specifically as an anti-cancer agent by the Salk Institute.

BRAF

Lack of BRAF V600E mutation in human myeloma cell lines established from myeloma patients with extramedullary disease

Targeting the BRAF V600E mutation in multiple myeloma

Targeting BRAF in multiple myeloma

alla hjärtans dag i Falun

Sweden's Tropical Paradise
Fårösund to Fårö

The island has no banks, post offices, medical services or police. and the ferry is free. It has it's own language, Gutnish and was strictly off-limits during the cold war. The Lamm never become sheep like in English or Fårö
as in Swedish.

Inhabited by thousands of Rauk (rock)and innumerable Lamm (lamb). 

The perfect vacation for your dog.

and children...

Inertial and gravitational mass in quantum mechanics

I found a fascinating a article.

Fredrik Swahn

Quest for Camelot - The Prayer

Viva La Vida

Djingis Khan (Dschinghis Khan)

Vad Vore Jag

För att du finns

Directions

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Gyllene Tider på Nya Gamla Ullevi

"Ullevi är ändå Ullevi som vi brukar säga"

An old TED talk on the E-Cat by the late Sergio Focardi

There are TED meetings being held in various parts of the world these days.  At a TED conference held in Bologna on October 14, 2011, Sergio Focardi, Emeritus Physics Professor of the University of Bologna, and collaborator with Andrea Rossi on developing the energy catalzyer, presented a talk on his work of the E-Cat entitled “L’E-cat e la fusione nucleare con il Nichel e l’Idrogeno”.  The English translation of the title is “The E-Cat and Fusion with Nickel and Hydrogen"

Stuck in a 2009 Timewarp

If anyone missed the music from the summer of 2009, now is a good time to catch up.

Linda Bengtzing

Linda sometimes has blonde hair, sometimes black and sometimes in between. No black in this selection of videos.

The Definition of Cool

I could not find a good definition of the word, cool, so I made up my own.

Swedes worry when they say “kul” meaning fun or funny, people will think they mean cool. Cool has come to mean “quite pleasantly acceptable in the current social context”, but dictionaries generally claim ignorance of what it really means.  In Danish, kul derives from Old Norse, “kol”, meaning coal in both languages.   Based on the old Anglo-Saxon meaning, English, as well as,in German, “kühl“, and Dutch, “ koel”, it still has the meaning of a “pleasantly low temperature” as distinct from chilly. In French, “col”, means col from the Latin word, “collum” meaning neck. When the word, “cool” appears in French or Swedish text, it means the English word.

Adding up the "ands" in the World

The story of “and” and “also”.  I was wondering when "also" became "and", but I kept thinking about  taihuntaihundaukanhund or  10X10=100. Why can't language be like that?

Gothic                   jah  meaning “and”;  auk meaning “also” or "but", aukan meaning "to add", og meaning "I fear"

Finnish                 ja      (gotiikka vaikutus?)

Saxon                    and / ond / und   (various spellings all meaning “and’ as do the others below:)

Old Norsk            ok 

Gutnish                 u  from Gothic "uh"

Old Swedish       oc

Swedish                och

Danish, etc         og         (Norwegian, Icelandic,etc)

English                 and

French                  et

German                und

Italian                   e          (also in Portuguese, Galician, etc.)

Czech                     a          (also in Welsh or Cymraeg)

Swahili                  na

Spanish                 y         (и in Russian, Serbian, Macedonian, etc.;  i in Polish)

Bahasa Melayu   dan      (and in Indonesian)

Etymology of “also”

·         Old English: ēac

·         Middle English: eek, ek

·         Scots: eik, ek

·         English: eke

·         Old Frisian: āk

·         West Frisian: ek

·         Old Saxon: ōk

·         Middle Low German: ôk

·         Low German: ok, ook (generally 'also', but 'and' in Pomeranian dialects due to the influence Swedish exerted during Sweden's occupation of Pomerania)

·         Plautdietsch: uk

·         Old Dutch: ōk, ouk, ouch

·         Middle Dutch: ooc

·         Dutch: ook

·         Afrikaans: ook

·         Old High German: ouh

·         Middle High German: ouch

·         German: auch

·         Yiddish: אויך (oykh)

·         Old Norse: auk, ok meaning “and”

·         Icelandic: og, auk

·         Faroese: og

·         Norwegian: og, òg, au

·         Swedish: och, ock

·         Danish: og

·         Gothic: auk

Latin
		et	meaning "and", "also", "for", "but", "however", or "when"
		ac	meaning "and"
		atque	meaning "and", "and yet", and "and further"
		autem	meaning "but", "however", "and", "moreover", and "also"
		que	meaning "and", "and lastly", "both ... and, as well as", "but", or "or"
		necnon	meaning "and"
		quod	meaning "because", "and", "fact that", "now," "although", or "whereas"
		adque	meaning "and", or "to"

Greek epísi̱s		επίσης	meaning “also”, “too”, “as well”, or “likewise”
		επί πλέον	meaning “moreover”, “furthermore”, “also”, or “over and above”

·         Hebrew

conjunction
		גַם	also, either, and
		אַף	also
		וְגַם	also
adverb
		כְּמוֹ כֵן	also, likewise, so, too
		וְכֵן	also
		גַם כֵּן	also, as well, too

Etymology of “and” (note: “and” became confused with “but” in Icelandic and then “than” in Scandinavia)

·         Old English: and, end, ond  meaning “and”

·         Scots: an  meaning “and”

·         English: and

·         Old Frisian: and, ende meaning “and”

·         North Frisian: en

·         West Frisian: en, in

·         Old Saxon: endi meaning “and”

·         Middle Low German: ende, unde

·         Low German: on, un, unde

·         Plautdietsch: un, en

·         Old Dutch: indi, in, enda, ande, anda

·         Middle Dutch: ende, en meaning “and”

·         Dutch: en  meaning “and”

·         Afrikaans: en meaning “and“

·         Old High German: unti, inti, enti, unta

·         German: und  meaning “and“

·         Old Norse: enn

·         Icelandic: enn  (became “en“ meaning “but“)

·         Faroese: enn meaning ”than”

·         Norwegian: enn  meaning “than”

·         Swedish: än  meaning ”than”

·         Danish: end  meaning ”than”

Greek  και meaning ”and”

Hebrew
		אֵת	meaning “and”
		גַם	meaning “also”, “either”, or “and”