Saturday, July 4, 2015
Multiple Myeloma
Multiple Myeloma is a cancer of the plasma cells. Cytoma formation is generally restricted to
the bone marrow and the infiltration of the skeletal structure including both
the interior and surface of the bone. The disease favors the creation of
osteoclasts over osteoblasts resulting in the resorption of bone mass. It begins with the central skeleton and expands
to the hand and feet extremities. Reaching the hand and feet is rare unless
bone destruction is arrested, because disintegration of bones in the central skeleton
is generally fatal. Progression of the disease crowds out the
normal functioning of the bone marrow. This results in anemia and immune suppression.
Also, the production of abnormal proteins can lead to the failure of kidney
function.
Four independent factors come together to produce the disease
state. These are categorized as (1)
genetic, (2) epigenetic, (3) viral, and (4) hormonal.
(1)
Genetic damage results from the accumulation of
strontium-90 in the developing skeleton.
Strontium-90 decays into short lived radioactive elements which decay
and irradiate the stem cells in the bone marrow niches causing the genetic
damage.
(2)
Epigenetic research points primarily to the
thymus and secondarily to the brain as the probable cause of Multiple
Myeloma. How the myeloma progenitor
cells mature into actual myeloma cells is not completely understood. Protease inhibitors only kill the mature
myeloma cells and do not affect progenitor cells from any of the known lines of
myeloma. Myeloma cells can develop a pump
mechanism to rid themselves of a particular protease inhibitor. Paw Paw Cell Regulator and possibly Sodium
DichloroAcetate may reduce the energy level in a Myeloma cell so it is unable
pump out the protease inhibitor.
(3)
Plasma stem cells travel from the bone marrow
niches to the spleen and lymph nodes where they encounter viral antigens which
are crucial to appropriate responses to viral infections and to the development
of Multiple Myeloma.
(4)
Hormonal responses to stress, nutrition, toxins,
and other environmental factors compromise the immune system and allow the disease
process to gain a foothold from which it can further suppress the immune
system. The cancer makes demands on the body’s supply of vitamin C and the body’s
ability to store vitamin D. Lowering the
levels of Interleukin-6 is also crucial to controlling the progression of the
disease.
Monday, January 12, 2015
Subscribe to:
Posts (Atom)
